Nos actions

Nos thèmes principaux de recherche concernent :

• Les leucémies aigues myéloblastiques
• Les leucémies aigues lymphoblastiques de la lignée T
• Les lymphomes de Hodgkin
• Les histiocytoses
• Les pathologies plaquettaires constitutionnelles
• Les cytopénies auto immunes
• Les neutropénies congénitales
• L’infection à VIH
• Le suivi à long terme des patients guéris d’un cancer durant l’enfance
• Les vaccinations
• La collaboration Franco Africaine

Voici quelques unes des publications les plus récentes du service sur ces différents sujets (le résumé de ces études est accessible en cliquant sur le titre)

Leucémies aigues myéloblastiques

Venetoclax Alone or in Combination With Chemotherapy in Paediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Myeloid Leukaemia.

Karol SE, Khaw SL, Zwaan CM, Baruchel A, Bittencourt H, Cooper TM, Flotho C, Fraser C, Forlenza CJ, Goldsmith KC, Macy ME, Morgenstern DA, O’Brien MM, Petit A, Ziegler DS, Reinhardt D, Opferman JT, Rubnitz JE, Onishi M, Dunshee DR, Dunbar F, Vishwamitra D, Ross JA, Chen X, Unnebrink K, Kammerlander M, Salem AH, Palenski TL, Sunkersett G, Place AE. Pediatr

Blood Cancer. 2025 Jul ;72(7) : e31714..

Isatuximab in combination with chemotherapy for pediatric patients with relapsed/refractory acute lymphoblastic leukemia or acute myeloid leukemia: The ISAKIDS study.

Baruchel A, Nysom K, Kang HJ, Felice MS, Michalowski MB, Freigeiro D, Epelman S, Lopes de Sousa AV, Valera ET, Moreira L, Leverger G, Nelken B, Kattamis A, Rizzari C, Fagioli F, Cesaro S, González-Llano O, Buechner J, Choque WQ, Duarte J, Abrahamsson J, Alarcón A, Wang L, Macé S, Oprea C, Abbadessa G, Zwaan CM.

Hemasphere. 2025 Oct 30 ;9(10) : e70245.

[SFCE harmonization workshops: Neonatal acute myeloid leukemia].

Ducassou S, Abou Chahla W, Duployez N, Halfon-Domenech C, Brethon B, Poirée M, Adam de Beaumais T, Lemaître L, Sirvent N, Petit A.

Bull Cancer. 2024 May ;111(5) :513-524.

Prognostic impact of RUNX1 mutations and deletions in pediatric acute myeloid leukemia: results from the French ELAM02 study group.

Lew-Derivry L, Marceau-Renaut A, Fenwarth L, Cuccuini W, Ballerini P, Ferreboeuf M, Guilmatre A, Petit A, Gandemer V, Rialland F, Schneider P, Michel G, Bertrand Y, Baruchel A, Preudhomme C, Leverger G, Lapillonne H.

Leukemia. 2023 Aug ;37(8) :1723-1726.

Leucémies aigues lymphoblastiques de la lignée T

Towards methylation-based redefinition of TAL1 positive T-cell acute lymphoblastic leukaemia (T-ALL).

Smith C, Charbonnier G, Simonin M, Balducci E, Steimle T, Andrieu GP, Cieslak A, Courgeon M, LeLorc’h M, Mayakonda A, Plass C, Le Nezet A, Latiri M, Ifrah N, Dombret H, Huguet F, Baruchel A, Macintyre E, Petit A, Boissel N, Asnafi V, Touzart A.

Leukemia. 2025 Oct ;39(10) :2344-2354.

Prognostic impact of the PredicT-ALL classifier in the AALL0434 trial: a model combining NGS, MRD, and WBC at diagnosis.

Simonin M, Boissel N, Petit A, Mullighan CG, Hunger SP, Loh ML, Winter SS, Macintyre E, Teachey DT, Baruchel A, Asnafi V.

Blood Adv. 2025 Oct 28 ;9(20) :5323-5326.

Oncogenomic profiling in infant-toddler T-ALL identifies NKX2 family genes as drivers linked to favorable outcomes.

Delafoy M, Balducci E, Simonin M, Pinton A, Charbonnier G, Courtois L, Lhermitte L, Gillet C, Féroul M, Touzart A, Cieslak A, Smith C, Courgeon M, Wiber M, Mercher T, Latour S, Arnoux I, Saultier P, Rohrlich PS, Bodet D, Grardel N, Lubnau M, Pellier I, Thouvenin S, Garnier N, Pastoret C, Brethon B, Petit A, Macintyre E, Baruchel A, Asnafi V.

Hemasphere. 2025 May 27 ;9(5) : e70154

Epigenetics-based stratification in pediatric T-ALL.

Simonin M, Touzart A.

Blood. 2025 May 8 ;145(19) :2108-2110.

Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL.

Balducci E, Simonin M, Duployez N, Steimlé T, Dourthe ME, Villarese P, Ducassou S, Arnoux I, Cayuela JM, Balsat M, Courtois L, Andrieu G, Touzart A, Huguet F, Petit A, Ifrah N, Dombret H, Baruchel A, Macintyre E, Preudhomme C, Boissel N, Asnafi V.

Blood. 2024 Aug 29 ;144(9) :988-1000.

Prognostic value and oncogenic landscape of TP53 alterations in adult and pediatric T-ALL.

Simonin M, Andrieu GP, Birsen R, Balsat M, Hypolite G, Courtois L, Graux C, Grardel N, Cayuela JM, Huguet F, Chalandon Y, Le Bris Y, Macintyre E, Gandemer V, Petit A, Rousselot P, Baruchel A, Bouscary D, Hermine O, Boissel N, Asnafi V.

Blood. 2023 Mar 16 ;141(11) :1353-1358.

Lymphomes de Hodgkin

Quantitative Deauville Scoring to Uncover Prognostic Information from ¹⁸F-FDG PET-Based Response Assessment: Data from the EuroNet-PHL-C1 Trial.

Kurch L, Landman-Parker J, Georgi TW, Attarbaschi A, Balwierz W, Beishuizen A, Braun M, Cepelova M, Ceppi F, Claviez A, Daw S, Dieckmann K, Fernández-Teijeiro A, Flerlage JE, Fosså A, Hjalgrim LL, Hraskova A, Karlén J, Klekawka T, Leblanc T, Montravers F, Lopci E, Mascarin M, Pears J, Pelz T, Prelog T, Rohde M, Sabri O, Steglich J, Stoevesandt D, Uytterbroeck A, Vordermark D, Wallace WH, Körholz D, Mauz-Körholz C, Kluge R, Hasenclever D.

J Nucl Med. 2025 Sep 2 ;66(9) :1331-1337.

Response-adapted omission of radiotherapy in children and adolescents with early-Should adolescents and young adults with Hodgkin lymphoma be treated as children or adults?

Lew-Derivry L, Chevillon F, Brice P, Bigenwald C, Landman-Parker J, Leblanc T, Boissel N, Cabannes-Hamy A.

Br J Haematol. 2025 Mar ;206(3) :907-918.

Classic Hodgkin Lymphoma: The LYSA pragmatic guidelines.

Rossi C, Manson G, Marouf A, Cabannes-Hamy A, Nicolas-Virelizier E, Maerevoet M, Alcantara M, Molina L, Ceraulo A, Poirée M, Galtier J, Diop N, Delette C, Segot A, Dubois S, Waultier A, Bernard S, Noël R, Guidez S, Kohn M, Bailly S, Moatti H, Touati M, Renaud L, Kanoun S, Cottereau AS, Kirova Y, Peignaux K, Dourthe ME, Simonin M, Leblanc T, Quéro L, Krzisch D, Duléry R, Grenier A, Gastinne T, Casasnovas O, Gallamini A, André M, Morschhauser F, Deau B, Fornecker LM, Ghesquières H.

Eur J Cancer. 2024 Dec ;213 :115073.

[Strategy of the French Society of Childhood Cancer (SFCE) for pediatric nodular lymphocyte predominant lymphoma].

Dourthe ME, Simonin M, Rigaud C, Haouy S, Montravers F, Ducou Le Pointe H, Garnier N, Minard-Colin V, Jo Molina T, Boudjemaa S, Leblanc T, Landman-Parker J.

Bull Cancer. 2023 Sep ;110(9) :968-977.

An update on molecular features and therapeutic perspectives of pediatric classical Hodgkin Lymphoma. What the clinician needs to know?

Simonin M, Jardin F, Leblanc T, Latour S, Landman Parker J.

Eur J Med Genet. 2023 Jan ;66(1) :104672.

Stage classical Hodgkin lymphoma and an adequate response to vincristine, etoposide, prednisone, and doxorubicin (EuroNet-PHL-C1): a titration study.

Mauz-Körholz C, Landman-Parker J, Fernández-Teijeiro A, Attarbaschi A, Balwierz W, Bartelt JM, Beishuizen A, Boudjemaa S, Cepelova M, Ceppi F, Claviez A, Daw S, Dieckmann K, Fosså A, Gattenlöhner S, Georgi T, Hjalgrim LL, Hraskova A, Karlén J, Kurch L, Leblanc T, Mann G, Montravers F, Pears J, Pelz T, Rajić V, Ramsay AD, Stoevesandt D, Uyttebroeck A, Vordermark D, Körholz D, Hasenclever D, Wallace WH, Kluge R.

Lancet Oncol. 2023 Mar ;24(3):252-261.

Histiocytoses

Childhood Langerhans cell histiocytosis hematological involvement: severity associated with BRAFV600E loads.

Thalhammer J, Jeziorski E, Marec-Bérard P, Barkaoui MA, Pagnier A, Rohrlich PS, Chevallier A, Carausu L, Aladjidi N, Rigaud C, Leruste A, Azarnoush S, Lauvray T, Le Louet S, Gandemer V, Treguier P, Mansuy L, Pasquet M, Olivier L, Rome A, Saultier P, Isfan F, Renard C, Li Thiao Te V, Salmon A, Blanc L, Abou Chahla W, Lambilliotte A, Stephan JL, Geissmann F, Lejeune J, Mallebranche C, Reguerre Y, Grain A, Thomas C, Hélias-Rodzewicz Z, Moshous D, Fenneteau O, Coulomb-L’Hermine A, Lapillonne H, de Saint-Basile G, Emile JF, Héritier S, Donadieu J.

Blood. 2025 Mar 6 ;145(10):1061-1073.

Quantitative Brain MRI Analysis in Neurodegenerative Langerhans Cell Histiocytosis.

Baek C, de la Rosa LR, Aliouat I, Guichard L, Pappa E, Le Guennec L, Nichelli L, Sangare A, Habert MO, Bayen E, Del Cul A, Mokhtari K, Cohen-Aubart F, Haroche J, Héritier S, Donadieu J, Hoang-Xuan K, Alentorn A, Idbaih A.

Eur J Neurol. 2025 Jun;32(6):e70249. doi: 10.1111/ene.70249.

Lung transplantation as a rescue option in childhood critical pulmonary Langerhans cell histiocytosis.

Heritier S, Donadieu J, Leger PL, De Tersant M, Della Vallee V, Barkaoui MA, Le Louet S, Tazi A, Taytard J, Corvol H, Helias-Rodzevicz Z, Emile JF, Fadel E, Fabre D, Feuillet S, Nathan N.

Pediatr Pulmonol. 2024 Jan ;59(1) :192-195 .

Pathologies plaquettaires constitutionnelles

Germline RUNX1 variants in paediatric patients in a French specialised centre.

Liu C, Ballerini P, Nguyen G, Mincheva Z, Copin B, Bouslama B, Leverger G, Petit A, Favier R, Lapillonne H, Boutroux H.

EJHaem. 2022 Nov 6 ;4(1) :145-152.

Efficacy and safety of recombinant activated factor VII in Glanzmann thrombasthenia: A systematic literature review.

Saultier P, Grino M, Falaise C, Voisin S, Lavenu-Bombled C, Ibrahim-Kosta M, Petit A, Boutroux H, Desprez D, Fiore M, d’Oiron R, Alessi MC.

Haemophilia. 2025 Jan ;31(1) :7-15.

Cytopénies autoimmunes

Childhood isolated C3d-positive AIHA: favorable prognosis but rare relapse or associated immunodeficiency.

Blachez M, Aladjidi N, Modot T, Fernandes H, Garnier N, Chastagner P, Bayart S, Armari-Alla C, Piguet C, Pasquet M, Paillard C, Pluchart C, Guitton C, Thomas C, Barlogis V, Pellier I, Stephan JL, Benadiba J, Jeziorski E, Deparis M, Carausu L, Cheikh N, Li-Thiao Te V, Lejeune J, Marie-Cardine A, Millot F, Abou Chahla W, Gay S, Alimi A, Petit A, Castelle M, Moshous D, Picard C, Rieux-Laucat F, Leblanc T, Ducassou S, Leverger G, Fahd M, Héritier S.

Blood Adv. 2026 Jan 27 ;10(2) :521-530.

Azathioprine or mycophenolate mofetil for pediatric autoimmune cytopenia: a propensity score-matched study.

Pincez T, Fernandes H, Leverger G, Barlogis V, Fahd M, Garnier N, Paillard C, Guitton C, Abou Chahla W, Pasquet M, Jeziorski E, Castelle M, Bayart S, Pellier I, Thomas C, Pagnier A, Benadiba J, Li Thiao Te V, Cheikh N, Lejeune J, Deparis M, Marie-Cardine A, Chastagner P, Desplantes C, Millot F, Vic P, Thouvenin S, Piguet C, Pluchart C, Leblanc T, Héritier S, Aladjidi N.

Blood Adv. 2026 Feb 10 ;10(3) :563-574.

Towards Targeted Therapies in Childhood Autoimmune Cytopenias: A Report on Leniolisib Use.

Alimi A, Maitre J, Hadjadj J, Laucat FR, Semeraro M, Picard C, Perdereau S, Leverger G, Héritier S.

Pediatr Blood Cancer. 2025 Apr ;72(4) : e31547.

Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia.

Schifferli A, Le Gavrian G, Aladjidi N, Moulis G, Godeau B, Leblanc T, Héritier S, Fernandes H, Kühne T.

Blood Adv. 2024 Dec 24 ;8(24):6183-6194.

Pediatric refractory chronic immune thrombocytopenia: Identification, patients’ characteristics, and outcome.

Pincez T, Fernandes H, Fahd M, Pasquet M, Chahla WA, Granel J, Ducassou S, Thomas C, Garnier N, Jeziorski E, Bayart S, Chastagner P, Cheikh N, Guitton C, Paillard C, Lejeune J, Millot F, Li-Thiao Te V, Mallebranche C, Pellier I, Castelle M, Armari-Alla C, Carausu L, Piguet C, Benadiba J, Pluchart C, Stephan JL, Deparis M, Briandet C, Doré E, Marie-Cardine A, Barlogis V, Leverger G, Héritier S, Aladjidi N, Leblanc T.

Am J Hematol. 2024 Jul ;99(7):1269-1280.

 Neutropénies

Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing.

Marti S, Pellet P, Beaupain B, Durix L, Buratti J, Réguerre Y, Aladjidi N, Azarnoush S, Clauin S, Chahla WA, Blaison G, Bertand J, Bodet D, Brethon B, Chane-Teng J, Delafoy M, Dupraz C, Gandemer V, Denizeau P, Goldenberg A, Hirsch P, l’Haridon A, Marie-Cardine A, Vera G, Nelken B, Nizery L, Nolla M, Pasquet M, Rosain J, Terriou L, Plo I, Donadieu J, Bellanné-Chantelot C.

Hemasphere. 2025 Jun 11 ;9(6) : e70150.

CXCR4 WHIM syndrome is a cancer predisposition condition for virus-induced malignancies.

Moulin C, Beaupain B, Suarez F, Bertrand Y, Beaussant SC, Fischer A, Durin J, Ranta D, Espéli M, Bachelerie F, Bellanné-Chantelot C, Molina T, Emile JF, Balabanian K, Deback C, Donadieu J.

Br J Haematol. 2024 Apr ;204(4) :1383-1392.

 Infection à VIH

Outcomes and challenges in adolescents with HIV in France: a nationwide cohort study over 35 years.

Dollfus C, Le Chenadec J, Reliquet V, Alby-Laurent F, Brehin C, Caseris M, Runel-Belliard C, Blanche S, Warszawski J, Faye A, Frange P; for the French ANRS-MIE CO10 Study Group.

AIDS. 2025 May 1 ;39(6) :667-675.

Sexual health indicators among young adults living with perinatally-acquired HIV in france, a gender-stratified comparison with their peers in the general population.

Ibrahim N, Bouyer J, Dollfus C, Viard JP, Faye A, Reliquet V, Arvieux C, Warszawski J, Rouquette A ; ANRS COVERTE-CO19 study group.

BMC Public Health. 2025 Oct 9 ;25(1) :3442.

Outcomes and challenges in adolescents with HIV in France : a nationwide cohort study over 35 years.

Dollfus C, Le Chenadec J, Reliquet V, Alby-Laurent F, Brehin C, Caseris M, Runel-Belliard C, Blanche S, Warszawski J, Faye A, Frange P ; for the French ANRS-MIE CO10 Study Group.

AIDS. 2025 May 1 ;39(6) :667-675.

Suivi à long terme

Chronic graft-versus-host disease in long-term survivors of childhood leukemia.

Saultier P, Michel G, Sirvent A, Renard C, Tabone MD, Leverger G, Baruchel A, Pochon C, Paillard C, Jubert C, Ducassou S, Poirée M, Strullu M, Fahd M, Visentin S, Stérin A, Plantaz D, Kanold J, Gandemer V, Theron A, Raus N, Thouvenin-Doulet S, Domenech C, Berbis J, Auquier P, Dalle JH.

Hemasphere. 2026 Jan 19 ;10(1) : e70298.

Long-term kidney complications in childhood leukemia survivors: a study from the Childhood and Adolescent Leukemia (LEA) project.

Domenech C, Saultier P, Hamidou Z, Tabone MD, Pasquet M, Gandemer V, Ducassou S, Poirée M, Plantaz D, Dalle JH, Chastagner P, Thouvenin S, Kanold J, Theron A, Pellier I, Reguerres Y, Baruchel A, Auquier P, Bacchetta J, Michel G, Derain-Dubourg L.

Haematologica. 2025 Sep 1 ;110(9) :1987-1997.

Adult height and growth hormone therapy in childhood acute lymphoblastic leukemia survivors treated with total body irradiation and hematopoietic stem cell transplantation before puberty.

Calvo C, Mornet C, Storey C, Halfon-Domenech C, Pochon C, Tabone MD, Leverger G, Baruchel A, Paillard C, Angoso M, Poirée M, Plantaz D, Kanold J, Gandemer V, Sirvent A, Thouvenin S, Pasquet M, Carel JC, Atger L, Berbis J, Auquier P, Dalle JH, Michel G, Saultier P.

Bone Marrow Transplant. 2025 May ;60(5) :718-720.

First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool.

Gille AS, Lenez L, Vanhæsebrouck A, Rivet-Danon D, Lapoujade C, Riou L, Dalle JH, Yakouben K, Peycelon M, Fahd M, Paye-Jaouen A, Leverger G, Tabone MD, Boutroux H, Irtan S, Chenouf C, Sibony M, Chalas C, Patrat C, Wolf JP, Boissel N, Fouchet P, Poirot C, Barraud-Lange V.

Bone Marrow Transplant. 2025 Jun ;60(6) :927-931.

Vaccinations

Safety and immunogenicity of BNT162b2 vaccine in children with acute leukaemia: results and perspectives of an open-label, two-centre, phase 1/2 trial with dose finding study.

Alby-Laurent F, Ouedrani A, Jateau P, Strullu M, Walter-Petrich A, Mrad C, Guilmatre A, Ferreboeuf M, Ray-Lunven AF, Kaguelidou F, Launay O, Chatenoud L, Morand-Joubert L, Chevret S, Petit A.

Vaccine. 2026 Feb 27 ;74 : 128130.

[Vaccination of children and adolescents treated for acute leukemia, excluding HSCT recipients: Recommendations of the French Society for Childhood and Adolescent Cancer and Leukemia (SFCE)].

Roussel A, Léglise C, Rialland F, Duplan M, Falaque F, Boulanger C, Cardine AM, Alimi A, Pochon C, Rabian F, Hautefeuille C, Corbel A, Dupraz C, Lervat C, Alby-Laurent F.

Bull Cancer. 2025 Feb ;112(2) :208-224.

Afrique

Epidemiology, incidence, and outcome of childhood cancers in the Afro-descendant population of the French West Indies and French Guiana: a population-based study.

Dichamp C, Lacour B, Clavel J, Dalle JH, Dufour C, Michaux K, Puget S, Faivre B, Delion F, Aigoun N, Hatchuel Y, Mascle J, Denailly H, Petit A, Leverger G, Orbach D, Berry J, Boissel N, Raimondo G, Sarnacki S, Cousin I, Dramé M, Baruchel A, Minard-Colin V, Felix A.

Lancet Reg Health Am. 2025 Mar 7 ;44 :101050.